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Pathway focused protein profiling indicates differential function for IL-1B, -18 and VEGF during initiation and resolution of lung inflammation evoked by carbon nanoparticle exposure in mice

Koustav Ganguly1 email, Swapna Upadhyay1 email, Martin Irmler2 email, Shinji Takenaka1 email, Katrin Pukelsheim1 email, Johannes Beckers2,3 email, Eckard Hamelmann4,5 email, Holger Schulz1* email and Tobias Stoeger1* email

Comprehensive Pneumology Center, Institute of Lung Biology and Disease, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstaedter Landstrasse 1, Neuherberg/Munich, D85764, Germany

Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstaedter Landstrasse 1, Neuherberg/Munich, D85764, Germany

Center of Life and Food Sciences, Technical University Munich, Weihenstephan, Alte Akademie 8, Freising, 85354, Germany

Department of Pediatric Pneumology and Immunology, Charité Universitätsmedizin Berlin, Augustenburger Platz 1, D-13353 Berlin, Germany

Department of Pediatrics, Ruhr-University Bochum, Alexandrinenstraße 5, 44791 Bochum, Germany

author email corresponding author email* Contributed equally

Particle and Fibre Toxicology 2009, 6:31doi:10.1186/1743-8977-6-31

Published: 2 December 2009

Additional files

Additional file 1:

Table S1. List of all the analyzed proteins along with their respective gene symbol, Entrez identification number, the least detectable dose (LDD )where applicable in our measurements and the associated gene ontology classifications according to Mouse Genome Informatics (MGI) database.

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