Table 3 |
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Summary of in vitro experiments related to gene expression in crocidolite-treated mesothelial cells |
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System |
Summary results |
Reference |
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Human mesothelial cells (LP9/TERT-1) exposed to low and high concentrations (15 and 75 μm2/cm2 per dish) for 8 or 24 h Oligonucleotide microarray analysis |
ATF3-dependent modulation of inflammatory cytokines and growth factor production |
[109] |
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Human SV40-immortalized pleural mesothelial (MeT-5A) cells exposed to 1 μg/cm2 dish for 1–48 h Oligonucleotide microarray analysis |
1 h: upregulation of nucleosome assembly, translational initiation, transcription, I-kappaB kinase/NF-kappaB cascade, survival 48 h: downregulation of cytoskeletal anchoring, transcription, survival |
[110] |
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Normal rat pleural mesothelial cells exposed to 5 μg/cm2 dish for 24 h Oligonucleotide microarray analysis |
Induction of fra-1-linked cd44 and c-met expression |
[111] |
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Jaurand et al. Particle and Fibre Toxicology 2009 6:16 doi:10.1186/1743-8977-6-16 |
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