Table 3

Summary of in vitro experiments related to gene expression in crocidolite-treated mesothelial cells

System

Summary results

Reference


Human mesothelial cells (LP9/TERT-1) exposed to low and high concentrations (15 and 75 μm2/cm2 per dish) for 8 or 24 h

Oligonucleotide microarray analysis

ATF3-dependent modulation of inflammatory cytokines and growth factor production

[109]


Human SV40-immortalized pleural mesothelial (MeT-5A) cells exposed to 1 μg/cm2 dish for 1–48 h

Oligonucleotide microarray analysis

1 h: upregulation of nucleosome assembly, translational initiation, transcription, I-kappaB kinase/NF-kappaB cascade, survival

48 h: downregulation of cytoskeletal anchoring, transcription, survival

[110]


Normal rat pleural mesothelial cells exposed to 5 μg/cm2 dish for 24 h

Oligonucleotide microarray analysis

Induction of fra-1-linked cd44 and c-met expression

[111]


Jaurand et al. Particle and Fibre Toxicology 2009 6:16   doi:10.1186/1743-8977-6-16

Open Data