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Immunoractivity of investigated antibodies in 15 Air and DE paired subjects participated in study. |
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| Immunoreactivity |
Air |
Diesel |
p value |
|
|
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| EGFR |
0.240 (0.100–0.370) |
0.690 (0.210–1.960) |
p = 0.004 |
| Tyr 845 |
0.220 (0.027–0.520) |
0.460 (0.160–1.030) |
p = 0.1 |
| Tyr 992 |
0.450 (0.320–0.580) |
0.530 (0.220–1.540) |
p = 0.14 |
| Tyr 1068 |
0.015 (0.002–0.250) |
0.180 (0.013–0.550) |
p = 0.18 |
| Tyr 1110 |
1.090 (0.560–2.140) |
1.780 (0.980–2.200) |
p = 0.39 |
| Tyr 1173 |
2.230 (1.380–2.890) |
3.160 (1.800–5.070) |
p = 0.02 |
| Tyr 416 |
0.033 (0.001–0.120) |
0.016 (0.003–0.800) |
p = 0.13 |
| MEK 1, 2 |
1.330 (0.310–2.670) |
1.410 (0.630–4.440) |
p = 0.28 |
| ERK 1, 2 |
0.140 (0.024–0.320) |
0.160 (0.045–0.650) |
p = 0.14 |
|
Two sections from each biopsy and exposure were evaluated during investigation of each antibody. Bronchial epithelium expression of EGFR, Tyrosine sites and downstream signalling immunoreactivity is given as percentage (%) positively stained area of the total measured epithelial area. All values are quoted as medians with inter-quartile range. Statistical comparisons by Wilcoxon's paired rank test. | |||
Pourazar et al. Particle and Fibre Toxicology 2008 5:8 doi:10.1186/1743-8977-5-8 |
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