|
DNA damage in A549 cells exposed to authentic street particulate matter for 24 hours. |
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| Filtera |
Dose (μg/ml) |
|||
|
|
||||
| Control |
2.5 |
25 |
100 |
|
|
|
||||
| Filter 1 |
||||
| SB |
0.143 ± 0.0208 |
0.122 ± 0.0185 |
0.411 ± 0.134 |
0.481 ± 0.149 |
| FPG |
0.069 ± 0.0452 |
0.066 ± 0.0286 |
0.205 ± 0.0690 |
0.191 ± 0.0488 |
| Filter 2 |
||||
| SB |
0.104 ± 0.00134 |
0.090 ± 0.00314 |
0.122 ± 0.0207 |
0.201 ± 0.0233 |
| FPG |
0.106 ± 0.0196 |
0.041 ± 0.0160 |
0.101 ± 0.0386 |
0.148 ± 0.0338 |
| Filter 3 |
||||
| SB |
0.116 ± 0.00947 |
0.097 ± 0.0160 |
0.352 ± 0.134 |
0.308 ± 0.0566 |
| FPG |
0.087 ± 0.0466 |
0.104 ± 0.0213 |
0.175 ± 0.0376 |
0.305 ± 0.0888 |
| Filter 4 |
||||
| SB |
0.104 ± 0.0134 |
0.089 ± 0.0153 |
0.127 ± 0.0110 |
0.453 ± 0.178 |
| FPG |
0.106 ± 0.0196 |
0.076 ± 0.0253 |
0.102 ± 0.0177 |
0.210 ± 0.0522 |
| Filter 5 |
||||
| SB |
0.150 ± 0.00919 |
0.197 ± 0.0415 |
0.218 ± 0.0395 |
0.399 ± 0.0309b |
| FPG |
0.289 ± 0.0266 |
0.513 ± 0.0552 |
0.415 ± 0.0584 |
0.621 ± 0.0276b |
| All filters |
||||
| SB |
0.123 ± 0.00975 |
0.119 ± 0.0204 |
0.246 ± 0.0586 |
0.368 ± 0.0512c |
| FPG |
0.131 ± 0.0400 |
0.160 ± 0.0888 |
0.200 ± 0.0575 |
0.295 ± 0.0853c |
|
a The data from filter 1–5 represent lesions/106 bp as mean ± SEM, n = 6. b Statistical significant compared to the control, p < 0.05 (Kruskal-Wallis test), Ntotal = 24. c Statistical significant compared to the control, p < 0.05 (randomized block ANOVA), the statistical analysis was based on the mean value of each filter (Ntotal = 20). | ||||
Danielsen et al. Particle and Fibre Toxicology 2008 5:6 doi:10.1186/1743-8977-5-6 |
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