Initial in vitro screening approach to investigate the potential health and environmental hazards of Envirox™ – a nanoparticulate cerium oxide diesel fuel additive

Barry Park¹ , Patricia Martin² , Chris Harris¹ , Robert Guest³ , Andrew Whittingham³ , Peter Jenkinson³ and John Handley³

¹Oxonica, 7 Begbroke Science Park, Sandy Lane, Yarnton, Oxfordshire, UK

²Product Assessment & Regulatory Compliance, Sydney Road, Cradley Heath, West Midlands, UK

³SafePharm Laboratories Ltd, London Road, Shardlow, Derby, UK

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Particle and Fibre Toxicology 2007, 4:12doi:10.1186/1743-8977-4-12


Published:	5 December 2007

Abstract

Nanotechnology is the new industrial revolution of the 21st Century as the various processes lead to radical improvements in medicine, manufacturing, energy production, land remediation, information technology and many other everyday products and applications. With this revolution however, there are undoubted concerns for health, safety and the environment which arise from the unique nature of materials and processes at the nanometre scale.

The in vitro assays used in the screening strategy are all validated, internationally accepted protocols and provide a useful indication of potential toxicity of a chemical as a result of effects on various toxicological endpoints such as local site of contact (dermal) irritation, general cytotoxicity and mutagenicity.

The initial in vitro screening strategy described in this paper to investigate the potential health implications, if any, which may arise following exposure to one specific application of nanoparticulate cerium oxide used as a diesel fuel borne catalyst, reflects a precautionary approach and the results will inform judgement on how best to proceed to ensure safe use.