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Morphological evaluation of the rat lungs after 2 hours perfusion and inhalation exposure to Ir-UFP, using lung sections and HE- or toluidine blue staining The regions investigated included the bronchial segment, the blood vessels and the alveolar region |
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| Treatment |
Bronchial region |
Blood vessels |
Alveolar region |
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| Control |
Sub epithelial round cell filtration; interstitial dilation |
Interstitial dilation |
Small alveolar dilation in periphery |
| Hydrogen peroxide |
Desquamation of epithelial layer, partially destruction of sub epithelial structure |
Moderate to severe dilation |
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| Histamine Perfusate |
Sub epithelial round cell filtration; interstitial dilation |
Moderate to severe interstitial dilation |
Alveolar dilation in periphery |
| Histamine (Bolus) |
Sub epithelial round cell filtration; interstitial dilation |
Moderate to severe interstitial dilation |
Focal alveolar dilation, oedematous fluid in alveolar lumen |
Meiring et al. Particle and Fibre Toxicology 2005 2:3 doi:10.1186/1743-8977-2-3 |
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